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FOXO6

Gründen Sie Ihre eigene Limited in UK oder Irland und US Firma, inkl. Bankkonto Fox Rage Eyewear. Schnelle lieferzeit: 1 bis 3 Arbeitstage! Die besten Deals für begeisterte Angler. Kundenbeurteilung 9,5/10 Forkhead box O6is a proteinthat in humans is encoded by the FOXO6 gene. FoxO6 is expressed in the liver, skeletal muscle, and the hippocampusof the brain. In the liver, FoxO6 normally promotes gluconeogenesisin the fasted state, but insulinblocks Fox06 upon feeding

Cancers | Free Full-Text | Role of FoxO Proteins in

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Diseases associated with FOXO6 include Rhabdomyosarcoma 2. Among its related pathways are FoxO signaling pathway and AMP-activated Protein Kinase (AMPK) Signaling FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene & protein UniProtKB - A8MYZ6 (FOXO6_HUMAN MGI:2676586, Foxo6: Phylogenomic databases. eggNOG i: KOG2294, Eukaryota: GeneTree i: ENSGT00940000161401: HOGENOM i: CLU_023456_1_0_1: InParanoid i: Q70KY4: OMA i: MLGMPQD: OrthoDB i: 1160384at2759: TreeFam i: TF315583: Enzyme and pathway databases. Reactome i: R-MMU-198693, AKT phosphorylates targets in the nucleus R-MMU-9614399, Regulation of localization of FOXO transcription. FoxO6 is the most recently identified FoxO-encoding gene and in mammals it was initially observed in the CNS [56-58]. FoxO6 is expressed in the hippocampus [56-58], is negatively regulated by insulin/IGF signaling vi

The reduced FoxO6 activity was closely associated with the elevation of oxidative stress in the skin of these animal models. To our interest, siRNA-mediated FoxO6 knockdown markedly increased melanin content and related signaling pathways in B16F10 cells even without any stimulation. On the contrary, adenovirus-mediated FoxO6 activation significantly reduced melanin content in UVB-exposed. FoxO6-null mice by substituting the first coding exon of FoxO6 with a neomycin cassette using homologous recombination in embryonic stem (ES) cells (Supplemen-tal Fig. 1A). Two independently targeted ES cell clones gave rise to male chimeric founders that transmitted the FoxO6-null allele to F1 offspring. Southern blots with three independent probes confirmed accurate homologous recombination. FoxO6 mRNA is particularly highly expressed in the hippocampus (Jacobs et al. 2003; Hoekman et al. 2006), a region important for learning and memory. Like other FoxO family members, FoxO6 is negatively regulated by the insulin/IGF signaling pathway in cells Human FOXO6 was identified in ESTs originating from brain tissue and tumor cell lines, and it shares about 95% amino acid identity with mouse Foxo6. In situ hybridization in mouse revealed restricted expression in the developing and adult brain, particularly in cortical and hippocampal structures (FoxO6) is a transcription factor mediating insulin signalling to glucose and lipid me- tabolism, therefore, dysregulated FoxO6 is involved in hepatic insulin resistance

Es ist ein Transkriptionsfaktor, der sich im Zellkern an bestimmte Stellen der DNA heftet und so die Transkription von Genen beeinflusst. Zur FOXO-Familie gehören beim Menschen noch FOXO1, FOXO4 und FOXO6. Das FOXO3 -Gen befindet sich beim Menschen auf Chromosom 6 Genlocus q21. Ein Pseudogen ist auf Chromosom 17 Genlocus p11 Results: The FoxO6 mRNA were 0.91±0.04, 1.72±0.07, and 2.03±0.06, and protein expression were 0.70±0.04, 1.35±0.08, and 1.56±0.07 in normal colon cell FHC, colorectal cancer cells HT116 and SW480, respectively. The protein and mRNA levels of FoxO6 in HCT116 and SW480 were significantly higher than those in FHC (both P <0.05) FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production Studies indicate that FoxO6 is produced in the liver of both rodents and humans. FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter FoxO-Proteine gehören zur umfangreichen Familie der Forkhead Box-Transkriptions-faktoren. Den vier FoxO-Proteinen des Menschen, die als FoxO1a, FoxO3a, FoxO4 und FoxO6 bezeichnet werden, steht in der Taufliege Drosophila melanogaster ein einziges Homolog gegenüber. Bei den FoxO-Transkriptionsfaktoren handelt es sich um eine evolutionär sehr alte und hochkonservierte Gruppe von Proteinen FoxO6 regulated nuclear factor erythroid 2-related factor (Nrf2) expression via c-Myc after 3% isoflurane preconditioning and OGD exposure. Thus, isoflurane preconditioning prevented OGD-induced injury in LO2 cells by modulating FoxO6, c-Myc, and Nrf2 signaling. High FOXO6 expression is associated with gastric cancer

Monoklonale und polyklonale Foxo6 Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für Foxo6 Antikörper. Hier bestellen The present study demonstrated that the expression levels of forkhead box O6 (FOXO6) were downregulated in lung cancer tissue samples, as compared with those in adjacent normal tissue. Overexpression of FOXO6 inhibited the proliferation of A549 human lung cancer cells, whereas knockdown of endogenous FOXO6 expression enhanced cell proliferation

Recombinant Forkhead Box O6 (Foxo6) Protein (His tag). Spezies: Human. Quelle: Insektenzellen. Jetzt Produkt ABIN3080155 bestellen FOXO6 - Explore an overview of FOXO6, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data The FoxO6 gene was mapped in region D1 on mouse chromosome 4. In humans, FOXO6 is located on chromosomal region 1p34.1. Embryonic expression of FoxO6 is most apparent in the developing brain, and FoxO6 is expressed in a specific temporal and spatial pattern. Therefore it is probably involved in regulation of specific cellular differentiation. In the adult animal FoxO6 expression is maintained. FoxO6-WT had low transactivation properties as compared with the FoxO6-Ala-184 under serum conditions and could be reduced even further by mutating FoxO6-Ser-184 to an aspartic acid (FoxO6-Asp-184). Serum starvation increased FoxO6-WT activity to a comparable level as found for the FoxO6-Ala-184 mutant. These data indicate that indeed the phosphorylation state of Ala-184 is essential in.

Involvement of the FOXO6 transcriptional factor in breast

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FoxO6 activation has been associated with metabolic syndromes including insulin resistance, hyperlipidemia, and fatty liver [11,12]. Liver-specific FoxO6-overexpressed mice exhibited hyperlipidemia because of enhancement of hepatic lipogenesis and VLDL secretion, and FoxO6 regulation was dysregulated in insulin-resistant mice FOXO6. Tissue specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more FOXO6 at chr1:41827106-41849262 - (NM_001291281) forkhead box protein O6 FOXO6-AS1 at chr1:41840676-41841341 - (NR_135817) NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*) FOXO6 antisense RNA 1 at chr1:41840676-41841341 - (NR_135817.1) Non-Human RefSeq Genes Foxo6 at chr1:41827594-41849263 - (NM_194060) forkhead box protein O6 foxo6.S at chr6:108882862-108985968 - (NM_001159282. Our FOXO6 polyclonal antibodies are developed in Rabbit. These antibodies have been verified by Knockdown to confirm specificity to FOXO6. Find the FOXO6 antibody that fits your needs. Choose from 1 of 4 FOXO6 antibodies, which have been validated in experiments with 5 publications and 16 images featured in our data gallery. Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and. FOXO6 (ENST00000641094.1) at chr1:41361931-41382678 - Homo sapiens forkhead box O6 (FOXO6), mRNA. (from RefSeq NM_001291281) FOXO6 (ENST00000643531.2) at chr1_KN196472v1_fix:111107-133486 - Homo sapiens forkhead box O6 (FOXO6), mRNA

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  1. Forkhead Box Protein O. Cite this entry as: (2018) FoxO6. In: Choi S. (eds) Encyclopedia of Signaling Molecules
  2. FoxO6 . FoxO6 is not only restricted to brain it is also expressed in peripheral tissue including liver, intestine, lung, kidney, muscle and adipose tissue [68]. In brain it is highly expressed in hippocampus, cerebellum, cortex. In adult murine brain's hippocampus, it is detected in region of dentate gyrus, CA1, CA2 and CA3. In mouse brain.
  3. Proteintech Anti-FOXO6 Polyclonal, Catalog # 19122-1-AP. Tested in Western Blot (WB), Immunohistochemistry (Paraffin) (IHC (P)) and Immunoprecipitation (IP) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 150 µL purified antibody (0.33 mg/mL)
  4. FOXO6 antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), CoImmunoprecipitation (IP), ChImmunoprecipitation (IP),Enzyme-linked Immunosorbent Assay (ELISA) applications. This antibody reacts with human, mouse, rat samples. Cat.No. 19122-1-AP
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FOXO6 - Wikipedi

  1. Consistently, FoxO6 deficiency results in decreased dendritic spine density in hippocampal neurons in vitro and in vivo. Thus, FoxO6 may promote memory consolidation by regulating a program coordinating neuronal connectivity in the hippocampus, which could have important implications for physiological and pathological age-dependent decline in memory. Keywords. consolidation; FoxO transcription.
  2. Complete information for FOXO6 gene (protein-coding), forkhead box O6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendiu
  3. Plasmid Flag-FOXO6 from Dr. Stefan Koch's lab contains the insert human FOXO6 and is published in Elsevier 2020 This plasmid is available through Addgene
  4. The following phenotype information is associated with a similar, but not exact match to this JAX ® Mice strain. Genotype: Foxo6 tm1Abru /Foxo6 tm1Abru. involves: 129S1/Sv * 129X1/SvJ * C57BL/6. behavior/neurological phenotype. abnormal temporal memory. Normal - however, learning of the conditioned behavior is normal
FOXO6 Antibody (NBP1-91611): Novus BiologicalsConstruction of eukaryotic expression vector of humanFoxO gene family evolution in vertebrates | BMC

Plasmid GST-FOXO6 from Dr. Anne Brunet's lab contains the insert FOXO6 and is published in J Biol Chem. 2007 Oct 12. 282(41):30107-19. This plasmid is available through Addgene Search for targets (e.g., 'ITK') or diseases (e.g., 'asthma') search. Submit Feedback feedbac Pathology i. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analyses based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 cancer patients is presented in a gene-centric manner. The green piechart indicates the level of. Showing 25 of 717 Results for FOXO6 Search Time: 0 ms Showing 25 50 100 200 500 See All of 717 Results for FOXO6 Search Time: 0 ms Expor FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by.

FOXO6 Gene - GeneCards FOXO6 Protein FOXO6 Antibod

Murine Foxo6 is a member of the murine forkhead family of transcription factors. This family consists of over 30 members, the vast majority of which is important in embryonic development. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons Functional Associations. FOXO6 has 1,254 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 39 datasets FOXO6: LocusID (NCBI) 100132074: Atlas_Id: 55618: Location: 1p34.2 [Link to chromosome band 1p34] Location_base_pair: Starts at 41361434 and ends at 41383590 bp from pter ( according to hg38-Dec_2013) Fusion genes (updated 2017) Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) Note: Non-annotated.

FOXO6 - Forkhead box protein O6 - Homo sapiens (Human

Foxo6 - Forkhead box protein O6 - Mus musculus (Mouse

FoxO6 Integrates Insulin Signaling WithGluconeogenesis in the Liver Dae Hyun Kim,1 German Perdomo,1 Ting Zhang,1 Sandra Slusher,1 Sojin Lee,1 Brett E. Phillips,1 Yong Fan,1 Nick Giannoukakis,1 Roberto Gramignoli,2 Stephen Strom,2 Steven Ringquist,1 and H. Henry Dong1 OBJECTIVE—Excessive endogenous glucose production con Carrying any Foxo6 Mutation: 7 strains or lines available: References: Original: J:191193 Salih DA, et al., FoxO6 regulates memory consolidation and synaptic function. Genes Dev. 2012 Dec 15;26(24):2780-801: All: 2 reference(s) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB. LifeSpan BioSciences currently sells 10 antibodies , 1 peptide specific for FOXO6

FOXO6 expression, at the first, was shown to be up‐regulated in gastric cancer tissues, although the mechanisms leading to its overexpression will be investigated in our further studies. Being classified to the FOXO family, FOXO6 is evolutionarily diverged from other FOXO members. FOXO6 shares the least homology (30%) in amino acid sequence with FOXO1, contains only two Akt/PKB. Foxo6 gene expression in Bgee. Rank scores of expression calls are normalized across genes, conditions and species. Low score means that the gene is highly expressed in the condition There are no reviews for FOXO6 Antibody (NBP1-91611). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen. Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen. Submit a Review Using EA as a proxy phenotype, we isolate FOXO6 and SLITRK1 as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP. AB - Higher educational attainment (EA) is negatively associated with.

FoxO6 regulates Hippo signaling and growth of the

NX_A8MYZ6 - FOXO6 - Forkhead box protein O6 - Sequence. Transcriptional activator FoxO6 mediates insulin action on target genes in a mechanism that is fundamentally different from other FoxO members. Here, we focus our review on the role of FoxO6, in contrast with other FoxO isoforms, in health and disease. We review the distinctive mechanism by which FoxO6 integrates insulin signaling to hepatic glucose and lipid metabolism. We highlight the importance of FoxO6.

FoxO transcription factors: Their roles in the maintenance

FoxO6 inhibits melanogenesis partly by elevating

5‐Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma Progression Through FoxO6 in AKT‐Dependent and Independent Manners. Xueliang Zuo. Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences; NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing, China. Thieme E-Books & E-Journals. 1 Klinik II und Poliklinik für Innere Medizin und Zentrum für Molekulare Medizin Köln (ZMMK), Universität zu Köln, Köln, Germany; 2 Institut für Vegetative Physiologie, Klinikum der Universität zu Köln, Köln, German

F1Fo-ATP Synthase β Subunit Operates by Affecting

FoxO6 regulates memory consolidation and synaptic functio

OMIM Entry - * 611457 - FORKHEAD BOX O6; FOXO

FOXO6 knockdown inhibited the proliferation and invasion and induced apoptosis of HCC cells. In addition, FOXO6 knockdown suppressed glycolysis, reversed resistance to chemotherapy in Hep3B/PTX cells and inactivated PI3K and Akt proteins, thus inhibiting the PI3K/Akt signaling pathway. Furthermore, it was found that when activated by 740Y-P, PI3K/Akt signaling pathway could resist the effects. Murine Foxo6 is a member of the murine forkhead family of transcription factors. This family consists of over 30 members, the vast majority of which is important in embryonic development. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons. Synonyms: Foxo6: Not shRNA sequences correspond to FOXO6 siRNA Gene Silencer sequences After transduction, stable cell lines expressing the shRNA may be isolated via selection with puromycin Biosafety - Lentiviral Particles are replication-incompetent and are designed to self-inactivate after transduction and integration of shRNA constructs into genomic DNA of target cells Sigma-Aldrich offers abstracts and full-text articles by [Frank M J Jacobs, Lars P van der Heide, Patrick J E C Wijchers, J Peter H Burbach, Marco F M Hoekman, Marten P Smidt] Nodes: Network nodes represent protein

Murine Foxo6 is a member of the murine forkhead family of transcription factors. This family consists of over 30 members, the vast majority of which is important in embryonic development. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons. Sequenc JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. You are using the latest 8th release (2020) of JASPAR FOXO6 becomes deregulated in the insulin-resistant liver, accounting for its enhanced activity in promoting gluconeogenesis and correlating with the pathogenesis of fasting hyperglycemia in diabetes . 7. Conclusion. FOXO transcription proteins modulate several cellular functions including proliferation, apoptosis, stress resistance, inflammation migration, and metabolism through regulation of.

Interaction between CHOP and FoxO6 promotes hepatic lipid

By Zhao Sun (283073), Clarissa S. G. da Fontoura (5818946), Myriam Moreno (5818949), Nathan E. Holton (5818952), Mason Sweat (5818955), Yan Sweat (5818958), Myoung. FoxO6-null mice are currently being generated. The four mammalian isoforms may have both distinct and overlapping functions, and compensation of one member by another may mask the function of individual FOXOs. Investigating the role of FOXO factors in longevity and tumor suppression will require more complex mouse models in which multiple Fox Structurally and functionally, Foxo proteins—which include Foxo1 (Fkhr), Foxo3a (Fkhrl1), Foxo4 (Afx) and Foxo6 and are all mammalian homologues of the Caenorhabditis elegans longevity and dauer. The forkhead box O (FOXO) family of transcription factors consists of four members: FOXO1, FOXO3, FOXO4 and FOXO6. At the cellular level, FOXO transcriptional targets are involved in the.

Forkhead-Box-Protein O3 - Wikipedi

An antibody shouldn't be one of the variables in your experiment. Find out why customers rank CST highest for antibody specificity and sensitivity Compare Anti-FOXO6 Immunohistochemistry Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more Forkhead box O 6 (FOXO6), a FOX transcription factor, has been found to be involved in diabetes mellitus and related complications. However, the role of FOXO6 in diabetic nephropathy (DN) has not been fully understood. In the present study, we evaluated the functions of FOXO6 in high glucose (HG)-induced glomerula FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity Kyoung Mi Moon, Bonggi Lee, Dae Hyun Kim, Hae Young Chung; Affiliations Kyoung Mi Moon Molecular Inflammation Research Center for Ageing Intervention (MRCA), Pusan National University, Busan, Republic of Korea; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University.

[Effects of FoxO6 on proliferation and invasion of

FoxO6 in the aging process may in part be related to its ability to attenuate oxidative stress by upregulating catalaseexpression,asshowninCR.Thisdelineationof the role of FoxO6 expands. View all transcripts of gene FOXO6; View all genomic variants; View all variants affecting transcripts; View all variants in gene FOXO6; Full data view for gene FOXO6; FOXO6 gene homepage. General information; Gene symbol: FOXO6: Gene name: forkhead box O6: Chromosome: 1: Chromosomal band: p34.2: Imprinted: Unknown: Genomic reference: NC_000001.10 : Transcript reference: XM_002342102.4. Compare Anti-FOXO6 Western Blot Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more

329934 - Gene ResultFoxo6 forkhead box O6 [ (house mouse)

In mammals, the FOXO family consists of FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO1, FOXO3a, and FOXO4 are widely expressed in various tissues, whereas FOXO6 is predominantly expressed in the brain . We therefore analyzed FOXO1, FOXO3a, and FOXO4 in the following experiments. Because all three of these FOXOs were expressed in C2C12 cells, we examined which ones are involved in SOD2's induction by. ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN memory (ortholog); positive regulation of dendritic spine development (ortholog); regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog

Sirt1 Inhibits Adipose Tissue Inflammation by Foxos/ mTORTargeting forkhead box transcription factors FOXM1 and

As FoxO6 pro-moter can be co-activated by PGC-1α and its promoter in turn can be repressed by FoxO6, it suggests that FoxO6 and PGC-1α form a regulatory loop for setting oxidative metabolism level in the skeletal muscle, which can be entrained by exercise. Key words: FoxO6, muscle, oxidative metabolism, PGC-1α, promoter, transcriptio FoxO6 expression becomes deregulated, accounting for its increased activity in insulin-resistant liver of mice with obesity and type 2 diabetes (20, 23). Unlike FoxO1 that undergoes insulin-dependent nuclear export, FoxO6 mediates insulin action on target gene expression in a distinct mechanism. Insulin inhibits FoxO6 activity by inducing FoxO6 phosphorylation and disabling its transcriptional. Foxo6 [nucleoplasm] Stable Identifier. R-MMU-961439 Gene: FOXO6 ENSG00000204060. Description. forkhead box O6 [Source:HGNC Symbol;Acc:24814] Location. Chromosome 1: 41,827,594-41,849,262 forward strand. GRCh37:CM000663.1. About this gene. This gene has 1 transcript (splice variant) and 4 paralogues. Transcripts. Show transcript table Hide transcript table. Name Transcript ID bp Protein Translation ID Biotype CCDS UniProt Match Flags; FOXO6-001. Downregulation of FOXO6 in breast cancer promotes epithelial-mesenchymal transition and facilitates migration and proliferation of cancer cells. Ye H; Duan M; Cancer Management and Research (2018) 10 5145-5156. DOI: 10.2147/CMAR.S157661. 9 Citations. Citations of this article. 11 Readers. Mendeley users who have this article in their library. Add to library View PDF. Abstract.

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